| Total | Partidos | Victorias | Empates | Derrotas | |||
|---|---|---|---|---|---|---|---|
| Total | 466 | 183 | (39%) | 134 | (29%) | 149 | (32%) |
| Casa | 231 | 123 | (53%) | 65 | (28%) | 43 | (19%) |
| Fuera | 235 | 60 | (26%) | 69 | (29%) | 106 | (45%) |
| Item | Competición | Local | Visitante | |
|---|---|---|---|---|
| Mayor victoria en casa | Apertura 2019 | Santos Laguna | 5-0 | Veracruz |
| Liga MX Apertura 2003/04 | Santos Laguna | 5-0 | Deportivo Irapuato | |
| Liga Mexicana Invierno 2001/02 | Santos Laguna | 5-0 | Monterrey | |
| Mayor victoria fuera | Liga Mexicana Apertura 2022/2023 | Pumas | 1-5 | Santos Laguna |
| Mayor derrota fuera | Apertura 2019 | Tigres | 4-0 | Santos Laguna |
| Apertura 2006 | Veracruz | 5-1 | Santos Laguna | |
| Liga Mexicana Invierno 2001/02 | Toluca | 6-2 | Santos Laguna | |
| Apertura 2005 | Jaguares | 5-1 | Santos Laguna | |
| Mayor derrota en casa | Liga Mexicana Apertura 2023/24 | Santos Laguna | 2-5 | Necaxa |
| Apertura 2005 | Santos Laguna | 1-4 | Tigres | |
| Apertura 2014 | Santos Laguna | 1-4 | América | |
| Apertura 2020 | Santos Laguna | 0-3 | Pachuca |
